Mastering Biochemical Raw Materials – Amino Acids, Enzymes, and Coenzymes by Handheld Raman

Biopharmaceutical and advanced therapy manufacturing involves a wide array of sensitive biochemical raw materials. Traditional handheld Raman devices often fail due to strong fluorescence from these biomolecules. The RS1500DI, with its 1064 nm excitation, overcomes this hurdle, making it the preferred choice for verifying amino acids, enzymes, coenzymes, and proteins. For example, aromatic amino acids like tyrosine and tryptophan are notorious for fluorescence under visible and NIR-short wavelengths – but the RS1500DI produces clear, identifiable spectra. Coenzymes such as NAD+, NADH, and coenzyme A, which are essential in cell culture media, are also successfully identified. The device can differentiate between various amino acid derivatives and detect the presence of target proteins in lyophilized powders. This capability is particularly valuable for quality control in biotech startups and large-scale fermentation facilities. Incoming lots of L-gluta-mine, methionine, or glutathione can be verified on the spot, preventing contamination or substitution errors.

The RS1500DI also supports identification of enzymes used as processing aids or final product components. Because the measurement is non-destructive and requires no sample preparation, valuable biochemicals are not wasted. The device’s user-friendly interface guides operators through the verification process, and its compliance with FDA 21 CFR Part 11 ensures that every test is documented for regulatory review. For manufacturers of cell culture media, parenteral nutrition, or enzyme replacement therapies, the RS1500DI is an indispensable quality assurance tool.

Technical Specification:

Wide Detection Range:

• Chemical raw materials: aspirin, folic acid, nicotinamide, etc.
• Medicinal excipients: salts, alkalis, sugars, esters, alcohols, phenols, etc.
• Packaging materials: polyethylene, polypropylene, polycarbonate, ethylene-vinyl acetate copolymer, etc.

Compared with ordinary 785nm Raman, it has stronger detection ability:

• Biochemical raw materials: amino acids and their derivatives, enzymes and coenzymes, proteins,etc.
• Color additives: carmine, carotenoids, curcumin, chlorophyll, etc
• Other polymer excipients: gelatin, microcrystalline cellulose, etc.

Penetrant packaging: No need for sampling, can be directly tested through woven bags, plastic, glass, and other packaging

Company Introduction:

JINSP offers over twenty spectroscopic products across various fields, including pharmaceutical and chemical industries, public security, and customs. Products are available nationwide and are exported to over 30 countries, with cumulative sales exceeding 3,000 units.

Benefit from 30+ R&D engineers, including 4 Ph.D., JINSP is deeply rooted in the field of personalized product customization, and is committed to meeting the diverse and unique needs of customers with excellent professional technology and innovative design capabilities.