1064nm Handhel Raman Conquering Fluorescence – Superior Performance on Challenging Samples

Fluorescence is the nemesis of conventional Raman spectroscopy. Many critical pharmaceutical ingredients – especially amino acids (e.g., tryptophan, tyrosine), coenzymes (e.g., NADH), cellulose derivatives, and certain color additives – produce overwhelming fluorescence under traditional 785 nm or 532 nm excitation, resulting in unusable spectra. The RS1500DI overcomes this fundamental limitation with its 1064 nm excitation wavelength. At this longer wavelength, fluorescence emission is dramatically reduced, allowing the weak Raman signal to emerge from the background. The result is clean, identifiable spectra for substances that other handheld Raman devices fail to measure.

In field tests, the RS1500DI successfully identified highly fluorescent samples such as riboflavin, chlorophyll, curcumin, and various amino acid formulations without any sample preparation. This capability expands the scope of Raman-based raw material identification to cover a much broader range of excipients and APIs. Furthermore, the device’s proprietary algorithms and spectral library have been optimized for low-signal-to-noise conditions, ensuring reliable matching even near the detection limit. For pharmaceutical quality control laboratories struggling with fluorescent interferences, the RS1500DI provides a practical, portable solution that eliminates the need for time-consuming separation or dilution methods. It turns formerly problematic materials into routine identifications, reducing delays and false rejections. Ultimately, the RS1500DI empowers manufacturers to confidently verify all incoming materials, not just the easy ones.

Technical Specification:

Wide Detection Range:

• Chemical raw materials: aspirin, folic acid, nicotinamide, etc.
• Medicinal excipients: salts, alkalis, sugars, esters, alcohols, phenols, etc.
• Packaging materials: polyethylene, polypropylene, polycarbonate, ethylene-vinyl acetate copolymer, etc.

Compared with ordinary 785nm Raman, it has stronger detection ability:

• Biochemical raw materials: amino acids and their derivatives, enzymes and coenzymes, proteins,etc.
• Color additives: carmine, carotenoids, curcumin, chlorophyll, etc
• Other polymer excipients: gelatin, microcrystalline cellulose, etc.

Penetrant packaging: No need for sampling, can be directly tested through woven bags, plastic, glass, and other packaging

Company Introduction:

JINSP offers over twenty spectroscopic products across various fields, including pharmaceutical and chemical industries, public security, and customs. Products are available nationwide and are exported to over 30 countries, with cumulative sales exceeding 3,000 units.

Benefit from 30+ R&D engineers, including 4 Ph.D., JINSP is deeply rooted in the field of personalized product customization, and is committed to meeting the diverse and unique needs of customers with excellent professional technology and innovative design capabilities.